Bitter gourd bioactive peptide alleviates neuronal ferroptosis after spinal cord ischemia-reperfusion injury, combined with emerging cell and animal models (opens in new tab)

BackgroundSpinal cord ischemia-reperfusion injury (SCIRI) remains a major clinical challenge with few effective treatments. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a key role in SCIRI pathology, and activation of the Nrf2/HO-1 pathway can counteract this process. Bitter gourd bioactive peptide (BGBP) is a natural low-molecular-weight peptide with antioxidant properties, but its effect on SCIRI induced ferroptosis is unknown. This study aimed to de...