Co-fermentation of Rosa roxburghii Tratt pulp by Saccharomyces cerevisiae and Bacillus subtilis alleviates diarrhea-predominant irritable bowel syndrome in mice by reshaping gut microbiota and host metabolism (opens in new tab)

BackgroundDiarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional bowel disorder closely associated with gut microbiota dysbiosis and gut-brain axis dysfunction. However, effective treatment options remain limited. In this study, we investigated the therapeutic effects and underlying mechanisms of an extract derived from the pulp of Rosa roxburghii Tratt after co-fermentation with Saccharomyces cerevisiae and Bacillus subtilis (referred to as FRRTP) in a mouse model of IB...