Taste receptor downregulation in diet-induced obesity reveals circumvallate papillae-specific taste-inflammatory networks (opens in new tab)

IntroductionBeyond their role in chemosensory perception, taste receptors function as metabolic regulators extra-orally. While decreased taste receptor expression in gustatory tissue is linked to obesity-associated inflammation, we tested the hypothesis that taste receptor-inflammation interactions extend to extra-oral contexts.MethodsObesity-associated metabolic syndrome-like phenotype was induced in female C57BL/6 mice by administration of a cafeteria diet for 18 weeks. The controls consume...