Clinical evidence for microbial-derived polyphenol metabolites in health and disease: a scoping review (opens in new tab)

BackgroundGrowing translational evidence indicates that the physiologically relevant effects of dietary (poly)phenols are largely mediated by gut microbial metabolism, resulting in bioactive microbial-derived (poly)phenol metabolites (MPMs). However, clinical evidence linking specific MPMs to defined health outcomes has not been comprehensively synthesized.ObjectiveThis scoping review characterizes clinical studies assessing associations between MPMs and human health and disease.MethodsWe sys...