Supplementation with 2′-fucosyllactose, a prebiotic human milk oligosaccharide (HMO), in a magnesium-containing medical food reduces chemotherapy-induced mucosi... (opens in new tab)

Mucositis is a common debilitating complication of chemotherapy in cancer patients that limits enteral nutrition, causes diarrhea, dehydration and electrolyte wasting. 2’-fucosyllactose (2’-FL), a non-digestible oligosaccharide initially isolated from human milk, is critical in the development of gastrointestinal function and microbiome maturation in the newborn. Here, we demonstrate, that supplementation of 2’-FL in a medical food with magnesium (Humolyte®), protects Wistar rats from gastroi...