Glycogen metabolic dysfunction in T2DM with MASLD: linking α-hydroxybutyrate to GYS2 downregulation (opens in new tab)

ObjectiveThis study aimed to investigate the molecular characteristics of T2DM with MASLD in a C57 mouse model, using multi-omics techniques to identify key nutritional metabolites that drive metabolic dysfunction. The goal was to reveal how metabolic disturbances are linked to transcriptional reprogramming, providing a new theoretical basis for nutritional biomarker discovery and targeted metabolic interventions.MethodsIn this study, a mouse model of T2DM with MASLD was established using a h...