Alhagi honey polysaccharide ameliorates carbon tetrachloride-induced liver fibrosis via modulating the gut microbiota-liver metabolism axis (opens in new tab)

BackgroundLiver fibrosis (LF) is a progressive injury that frequently advances to cirrhosis and hepatocellular carcinoma, yet effective intervention strategies remain limited. Alhagi honey polysaccharide (AHPN), a bioactive macromolecule with a molecular weight of 9.35 × 10ł Da primarily composed of mannose (29.384%), glucose (41.804%), and galactose (28.810%), represents a promising candidate for antifibrotic therapy.MethodsThis study established a carbon tetrachloride (CCl4)-induced liver f...