Efficacy of antioxidants as a therapy for Alzheimer's disease: a meta-analysis (opens in new tab)

BackgroundOxidative stress plays a central role in the pathogenesis of Alzheimer's disease (AD), contributing to neuronal damage, amyloid-beta aggregation, tau hyperphosphorylation, and neuroinflammation. Although antioxidants have been proposed as potential therapeutic agents, clinical trials have yielded inconsistent results.ObjectiveTo systematically evaluate the efficacy of various antioxidants—including vitamins, polyphenols, and other antioxidant preparations—on cognitive function, oxid...