Mitochondrial dysfunction in EEG: high-beta specific metabolic/oxidative coupling with lactate in mania-predominant polarity (opens in new tab)

Psychiatric diseases are progressively recognized as disruptions in brain dynamics that can be measured using electrophysiological and metabolic indicators. Conventional EEG investigations utilizing power spectra or standard entropy metrics (sample entropy, multiscale entropy, permutation entropy) have shown diagnostic significance but are constrained in their ability to capture higher-order relationships. This work combines psychiatric ideas with sophisticated mathematical methods to discove...