Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition (opens in new tab)

Dendritic spine loss on superficial layer pyramidal neurons in the prefrontal cortex (PFC) has emerged as a central neuropathological feature across a range of neuropsychiatric disorders. This is particularly significant as the PFC serves as a critical hub for higher-order cognitive functions such as working memory, attention regulation, and decision-making, which are often disrupted in neuropsychiatric disorders. These cognitive functions rely on the integration of local and global inputs wi...