Rapid reduction of suicidal ideation with transient dissociative and “drunken gait” symptoms after intranasal esketamine, with music intervention: a case report (opens in new tab)

BackgroundTreatment-resistant depression (TRD) is often accompanied by persistent suicidal ideation and poor response to conventional antidepressants. Intranasal esketamine, a non-selective NMDA receptor antagonist, provides rapid antidepressant and anti-suicidal effects; transient dissociation is common, whereas ataxia-like “drunken gait” is rarely described.Case presentationA 19-year-old woman with recurrent depression and multiple prior suicide attempts received two courses of intranasal e...