Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study (opens in new tab)

BackgroundGenetic factors can influence variation in cardiac structure. Schizophrenia (SCZ) is also highly heritable. However, whether cardiac structural variation is related to SCZ risk remains unclear and insufficiently examined from a "heart-to-brain" perspective.MethodsUsing data from 38,206 UK Biobank (UKB) participants, we assessed associations between 16 cardiac magnetic resonance imaging-derived ventricular traits and SCZ polygenic risk scores. Using ventricular cardiac magnetic reson...