Cell type-specific alterations in fatty acid metabolism in neuronal subpopulations of schizophrenia and construction of a diagnostic model (opens in new tab)

ObjectiveThis study integrates single-cell and bulk RNA-seq to investigate cell type-specific alterations in fatty acid metabolism-related genes in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia (SCZ) patients and to evaluate their potential as diagnostic biomarkers.MethodsIntegrating single-cell sequencing data (9 SCZ patients and 14 controls) and Bulk RNA-seq data (GSE174407, GSE107638), cell subpopulation identification and annotation were performed using Seurat. Key genes wer...