Case report: Effective treatment of posttraumatic aggression in a child affected by TBI treated with long-acting injectable paliperidone: a case study and literature review (opens in new tab)

Post-traumatic confusional state (PTCS) is a disabling sequel of pediatric traumatic brain injury (TBI), with little guidance on pharmacologic management when aggression and poor impulse control dominate and adherence is poor. We describe a 9-year-old boy with severe TBI who evolved from coma to a prolonged PTCS characterized by agitation, externalizing behaviors, and dysexecutive symptoms. Multiple oral agents—risperidone, methylphenidate, olanzapine, and aripiprazole—were trialed over sever...