Age-dependent gray matter volume alterations in healthy siblings of schizophrenia patients: a structural magnetic resonance imaging study (opens in new tab)

Schizophrenia (SCZ) is a severe neurodevelopmental mental disorder with age-dependent onset, and healthy siblings of SCZ patients are a pivotal cohort for exploring genetic susceptibility. This study aimed to characterize age-differentiated gray matter volume (GMV) patterns in high-risk and non-high-risk age siblings of SCZ patients via structural magnetic resonance imaging (sMRI), and clarify the regulatory role of age in neurostructural correlates of genetic susceptibility. A total of 31 SC...