Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study (opens in new tab)

BackgroundCognitive control deficits are a core feature of adolescent major depressive disorder (MDD), yet the associated task-state neurophysiological mechanisms remain poorly characterized. This study investigated electrophysiological alterations in MDD using a Stroop color-word task.MethodsTwenty-two adolescents with MDD and fifteen age- and sex-matched healthy controls (HC) completed the task during 32-channel EEG recording. We analyzed P300 amplitude and latency, 1-30Hz power spectral de...