A multi-scale mathematical framework for modelling the dynamic nature of autism spectrum disorder symptoms: integrating predictive coding, information theory, and network principles (opens in new tab)

BackgroundAutism Spectrum Disorder (ASD) is characterised by persistent deficits in social communication and interaction alongside restricted, repetitive patterns of behaviour, interests, or activities. Standard diagnostic criteria provide static descriptions, failing to capture the dynamic variability of these symptoms across contexts and developmental trajectories. Furthermore, current descriptions often lack mechanistic explanations for why these symptom fluctuations occur. There is a need...