Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation (opens in new tab)

BackgroundCadmium(Cd) exposure is associated with anxiety, but mechanism-informed multi-target interventions are limited.MethodsWe profiled plasma proteomes by LC-MS/MS in a propensity-score-matched Cd-exposed cohort (25 anxious vs 25 non-anxious). Anxiety-associated proteins were used as seeds for reverse screening in TCMIP v2.0, followed by network integration, molecular docking, 100ns molecular dynamics simulations, and rat validation of a ginseng-mulberry leaf (medicine-food homologous) d...