Functional MRI evidence of brain alterations in premenstrual dysphoric disorder: a systematic review (opens in new tab)

IntroductionPremenstrual Dysphoric Disorder (PMDD) affects approximately 1.6% of women of reproductive age and significantly impacts quality of life. Despite its prevalence, the underlying pathophysiology remains incompletely understood. First-line treatment typically involves selective serotonin reuptake inhibitors (SSRIs); however, approximately 40 percent of women with PMDD do not respond to these medications. This systematic review synthesizes current evidence on functional brain alterati...