Sleep duration, depressive symptoms, and postoperative delirium: a mediation analysis (opens in new tab)

PurposeThe mechanism linking postoperative sleep duration to postoperative delirium (POD) remains unclear. This study examined the potential indirect pathway involving depressive symptoms (assessed via the PHQ-9) in the association between postoperative sleep duration and POD.MethodsWe included 500 patients aged ≥ 65 years undergoing unilateral total hip or knee arthroplasty under general anesthesia. The associative pathways among sleep duration, depressive symptoms, and POD were assessed usi...