Violence and threat exposure is associated with frontostriatal alterations during risky decision-making in children with co-morbid ADHD and disruptive behavior disorders (opens in new tab)

IntroductionEarly life adversity (ELA) is prevalent in the US and is associated with a number of risky behaviors, including substance use. Recent work has shown that specific forms of ELA, including violence exposure and threat exposure, is associated with alterations in reward and attentional neuro-circuitries implicated in risky decision-making. Although a couple of studies have examined the relationship between ELA and neural alterations in youths at high risk for substance use disorders (...