Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants (opens in new tab)

IntroductionDepression is a significant global health burden, with low- and middle-income countries disproportionately affected due to stigma, limited mental health resources, and imprecise diagnosis and treatment. In Latin America, reliance on non-specialized care further contributes to heterogeneous clinical outcomes. Although personalized medicine offers opportunities to improve depression management, genetic research has largely underrepresented Latin American populations, limiting unders...