Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms (opens in new tab)

Extrapyramidal syndrome (EPS) refers to a group of movement disorders resulting from dysfunction of the extrapyramidal system (motor pathways outside the pyramidal tract). Among the various pathogenic factors of EPS, chronic or long-term use of antipsychotic drugs (APDs) is worth special note. This article aims to provide a comprehensive review on the application of phytomedicines in preventing and treating the APDs-induced EPS or EPS-like behaviors by summarizing their therapeutic effects an...