Computational phenotyping of effort-based decision-making in type-2 diabetes on and off semaglutide (opens in new tab)

Motivation plays a fundamental role in human behaviour. Dopaminergic pathways have long been implicated in individual differences in motivation. Emerging evidence suggests such neural mechanisms interact with metabolic processes to coordinate energy expenditure with energy resources, thereby linking motivation with metabolic health. We ask whether a cognitive-computational index of motivation—reliably linked to neuropsychiatric symptoms—is altered in the context of type-2 diabetes and treatme...