Caspase-3/Drice as a critical regulator of actin dynamics through its dual control of small RhoGTPase family and Gelsolin in the Malpighian tubules of Drosophil... (opens in new tab)

Caspases are well-known executioner enzymes that drive programmed cell death. However, growing evidence indicates their crucial non-apoptotic functions in regulating proliferation, differentiation, endocytic trafficking, cell polarity, morphogenesis, and immune responses. In this study, we uncover a novel role of the Drosophila caspase-3 homolog, Drice, in the spatial and dynamic regulation of actin filaments during the development and functional maintenance of Malpighian tubules (MTs). Our p...