Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation (opens in new tab)

Cardiac chambers emerge from a heart tube that balloons and bends to create expanded ventricular and atrial structures, each containing a convex outer curvature (OC) and a recessed inner curvature (IC). The cellular and molecular mechanisms underlying the formation of these characteristic curvatures remain poorly understood. Here, we demonstrate in zebrafish that the initially similar populations of OC and IC ventricular cardiomyocytes diverge in the organization of their actomyosin cytoskele...