Experimental assessment of AI-based interactome mapping (opens in new tab)

Genotype-phenotype relationships are mediated through intricate networks of physical and functional interactions among macromolecules. Knowledge of the interactome is vital to understand and model genetics and cellular biology. Recent advances in accurately predicting tertiary protein structures using artificial intelligence (AI) approaches such as AlphaFold1 have revived the vision that the protein-protein interactome might be fully predictable through computational modeling of quaternary st...