Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants (opens in new tab)

Vascular plants and metazoans use selective proteolysis to control responses to hypoxia, although through distinct biochemical mechanisms. The reason for this divergence is puzzling, since the molecular components necessary for both strategies are conserved. To explore the alternative scenario where plants and animals respond to hypoxia through the same mechanisms, we engineer a three-components system aimed to target proteins for degradation in an oxygen dependent manner in Arabidopsis thali...