A single-cell and spatial atlas of early human olfactory development (opens in new tab)

The human nasal region arises from neural crest and placodal lineages, yet its early development remains poorly understood owing to limited fetal tissue access and structural complexity. Here we present an integrated single-nucleus and spatial transcriptomic atlas of the human fetal nasal region, generated from male and female fetuses between 7 and 12 post-conceptional weeks. Single-nucleus RNA sequencing [snRNA-seq] resolved 32 distinct cell types, while integration with multiplexed error-ro...