Metabolic adaptation drives self-organization during skin organoid morphogenesis (opens in new tab)

Self-organization in organoid morphogenesis involves the coordinated arrangement of interacting cells into higher-order structures, yet the underlying principles remain elusive. Here, we investigate how epidermal and dermal cells respond distinctively to elevated levels of hypoxia during skin organoid morphogenesis that largely resembles the skin development during embryogenesis. We unveil that autonomously generated hypoxic environment-induced metabolic adaptation drives the transition from ...