Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity (opens in new tab)

Large-scale brain activity at rest is thought to wander among a discrete set of attractor-like functional configurations shaped by underlying structural connections, yet how state-transitions are perturbed in major depressive disorder remains unknown. Here, we integrate resting-state functional imaging and diffusion-weighted structural connectivity in individuals with and without major depressive disorder to identify stable, recurring whole-brain coactivation patterns. More frequent and short...