Mild-Sunlight-Activated Safe Photodynamic Therapy Using On-Off Polymer Photosensitizers in Wearable Microneedle Patch (opens in new tab)

Photodynamic therapy (PDT) is promising but limited by its dependence on specialized photosources, clinic-based administration, and prolonged post-treatment light avoidance due to phototoxicity side effects. Here, we report mild-sunlight­activated PDT (SunPDT) microneedle patches incorporating polymeric photosensitizers with an intrinsic “on-off” reactive oxygen species (ROS)-generating mechanism, enabling bio-safe, deep-tissue, and self-administered PDT without fixed clinic visits and strict...