Genetically engineered hookworms can now secrete human therapeutic antibodies directly into their host's circulation, offering a potential single-dose, years-lo... (opens in new tab)

Biologics, protein- and peptide-based drugs derived from living organisms or cell lines have emerged as effective therapies across a broad range of indications. However, parenteral administration and the need for frequent dosing increase costs and limit compliance, creating an urgent need for innovative platforms capable of continuously, safely, and efficiently delivering sustained biologics in situ within the host. Here, we describe a bioengineered hookworm platform to manufacture and delive...