Enantioselective construction of polychiral helical compounds via dynamic kinetic resolution (opens in new tab)

Chiral helicenes and their derivatives are valuable across diverse research fields, yet the development of helical chirality has lagged far behind that of point and axial chirality. The synthesis of polychiral or heteroatom-containing helical systems remains especially challenging because of limited starting materials and difficulties in stereochemical control. Here we computationally design a flexible oxa[4]helicenoid-ol scaffold with an optimal rotational barrier (ΔG‡ = 21.7 kcal mol−1) and...