Behavioral correlates of Purkinje cell ensemble covariance (opens in new tab)

Purkinje cells (PCs) mediate adaptive cerebellar output through inhibitory control of the cerebellar nuclei. Because many PCs converge, their influence on target neurons likely depends on population activity. However, despite a large literature on individual PC relationships with behavior, little is known about how multiple PCs collaborate to influence movement. In simultaneously recorded PCs during mouse forelimb reach behavior, we found that different kinematic variables correlated either w...