Cobaloxime-catalysed regiodivergent hydrogen atom transfer for alkenyl and allylic carbamoylation with branched alkenes (opens in new tab)

Hydrogen atom transfer (HAT) represents a fundamental reaction in synthetic chemistry, with ongoing innovations aimed at improving its selectivity and efficiency. Leveraging the unique reactivity of cobaloxime, we developed a regioselective HAT process that enables divergent carbamoylation of branched alkenes. Through modulation of the electronic and steric properties of the ligands, this cobalt complex achieves precise discrimination between hydrogen atoms exhibiting minor differences in bon...