Practical and divergent electrochemical access to thiocarbamoyl fluorides and N -trifluoromethyl amines from secondary amines (opens in new tab)

We report a practical and divergent electrochemical method for converting simple secondary amines into thiocarbamoyl fluorides and N-trifluoromethyl amines. Using inexpensive, bench-stable reagents, including Et₃N·3HF and CS₂, these one-pot transformations proceed under mild, open-air conditions without solvent drying, degassing, inert atmosphere, or stoichiometric silver reagents. By tuning the reaction conditions, the same general strategy provides either product class in moderate to excell...