Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson’s disease (opens in new tab)

Disruption of circadian rhythms is a key feature of neurodegenerative diseases and a non-motor feature of Parkinson’s disease, which significantly impairs health-related quality of life; yet, the underlying mechanisms are only partially understood. Preclinical animal models with neuropathological and symptomatic significance might contribute to a better understanding of circadian dysfunction. Here, we investigated light-dark phase-dependent modulation of motor and non-motor behavior as well a...