Inferring relationships among major psychiatric disorders in a resting-state functional connectivity-informed embedding space (opens in new tab)

Major neuropsychiatric disorders such as major depressive disorder (MDD) and schizophrenia (SCZ), as well as the neurodevelopmental disorder autism spectrum disorder (ASD), are traditionally treated as distinct clinical entities. However, genome-wide association studies indicate shared genetic risks, motivating a transdiagnostic view. Resting-state functional connectivity (rsFC) is a promising biomarker for these disorders, but its high dimensionality complicates inference of inter-disorder r...