CellTarget: a convex optimisation approach to discover cellular objectives (opens in new tab)

Metabolic network models are widely used in systems and synthetic biology to study cellular metabolism from microbes to mammals. However, their application to mammalian cells remains limited by the scarcity of intracellular flux measurements relative to network size. As a result, mammalian metabolic models are typically underdetermined and require optimisation-based assumptions to be solved. Unlike microbial systems, mammalian cells do not generally operate under growth-maximising objectives,...