In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives (opens in new tab)

Computational medicine uses mathematical modelling, high-performance computing, and the availability of large-scale biomedical data to study multiscale complex diseases. This review synthesises recent developments in in silico oncology, neurology, and epidemiology, highlighting their shared methodological foundations in systems theory and complex networks. We discuss how combining mechanistic approaches with machine learning integrates heterogeneous data. Finally, we identify translation barr...