Emerging materials and technologies towards in situ biomanufacturing (opens in new tab)

In situ biomanufacturing is redefining personalized and regenerative medicine by enabling therapeutic materials to be formed directly at target sites within the body. This emerging paradigm integrates advances in biomaterials, minimally invasive surgical tools and robotic systems, and ultrasound-guided activation platforms to achieve precise, on-demand material deposition or crosslinking without the need for open surgical access. This Review outlines the clinical challenges and requirements m...