Emerging evidence for a cooperative pathway of Hedgehog release (opens in new tab)

All Hedgehog (Hh) morphogens undergo dual lipidation during biosynthesis. This process renders them insoluble; however, with the help of several accessory release factors, both lipids also regulate subsequent Hh solubilization and transport. Here, we propose that these accessory factors interact synergistically rather than in alternative or mutually exclusive ways. Several mechanisms have been described for the release and transport of Hedgehog morphogens. Here, Grobe and Puschmann propose a ...