Large-scale electrophysiology at single-spike resolution (opens in new tab)

Recent advances in electrode technology — including the development of Neuropixels and SiNAPS probes — have made it possible to routinely capture spike trains from thousands of neurons distributed across the brain. Widespread dissemination of these tools has not only yielded new discoveries but also changed the way in which neuroscientific questions are asked and answered. In this article, we describe the motivations for collecting electrophysiological recordings on this scale, review the bas...