The AMPA receptor life cycle: assembly, regulation and synaptic diversity (opens in new tab)

AMPA receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the mammalian brain. Recent structural, functional and proteomic advances have reshaped our understanding of how these receptors assemble, gate and diversify within distinct synaptic environments. Notably, AMPAR function is governed by an interlocking set of regulatory layers that include alternative splicing and RNA editing within regions of the receptor subunits responsible for gating and permeation, and di...