m6A in RNA: a key regulator of brain development, function and disease (opens in new tab)

Epitranscriptomic regulation of cellular RNAs is a major mechanism of gene expression control in the brain. N6-Methyladenosine (m6A) is installed on thousands of mRNAs and non-coding RNAs, where it functions as a context-dependent regulator of RNA–protein interactions to control the amplitude and kinetics of gene expression. In the nervous system, m6A is critical for neurodevelopment, synaptic plasticity and adaptive responses to physiological stimuli, and its dysregulation has been linked to...