Acetylcholine: a candidate substrate for hippocampal predictive learning? (opens in new tab)

Acetylcholine release in the hippocampus has been associated with diverse neural functions in learning and memory, including novelty, uncertainty detection, error correction, arousal and hidden state inference, while also modulating theta oscillations. Confronted with this plurality of roles, a unifying framework for interpreting cholinergic function is lacking. Recently, predictive models have emerged as a normative lens for understanding neural function, viewing the brain as learning to pre...