The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner (opens in new tab)

The development of the mammary gland is a complex process that evolves throughout life. It can undergo drastic changes to support lactation, before involuting back to a rudimentary organ after weaning, in a perfectly orchestrated mechanism. This study aimed to identify the pathways coordinating mammary gland organogenesis, using mouse organoids as a model. In developmental assays, the mechanistic target of rapamycin (mTOR) was shown to be a regulator of cellular lineage determination and bran...