Modeling optimal timing of immunotherapy and chemotherapy to prevent resistance and recurrence in triple-negative breast cancer (opens in new tab)

One intrinsic characteristic of Triple Negative Breast Cancer (TNBC) is its high plasticity, resulting in heterogeneous cancer cell subpopulations with distinct interactions with the immune system. To address TNBC plasticity, we set to model the dynamics of tumor cell subpopulations derived from the murine TNBC-like 4T1 cell line, by developing a system of ordinary differential equations (ODEs) based on experimental results, distinguishing between Sca1⁺ (Stem Cell Antigen 1) and Sca1⁻ cells a...