Effects of a single dose of L-histidine on mental fatigue and vigor in participants with high fatigue levels: a randomized controlled trial (opens in new tab)

Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity that affects many aspects of daily life. Two weeks of L-histidine daily ingestion in humans significantly improves mood states compared with a placebo; however, the effects of a single dose are unknown. We aimed to assess the effects of a single dose of L-histidine on mood states, including fatigue, in healthy men and women who regularly experienced fatigue and sleep deprivation. Participant...